Abstract: The venoms of arthropod predators such as spiders, scorpions and centipedes are dominated by disulfide-rich

peptides that evolved to target neuronal ion channels in prey and predators. We use these natural combinatorial libraries

of ion channel modulators to isolate peptides that target ion channels involved in human nervous system diseases. I will

show recent examples from our lab of spider-venom peptides with very different modes of action that are providing leads

for the treatment of epilepsy and stroke. I will describe the discovery and biophysical characterization of these peptides,

including their 3D structure and mode of action, and demonstrate their therapeutic effects in relevant animal models .

About CAI Seminar Series

The perfect opportunity to attend cutting-edge research presentations involving CAI researchers or collaborators, each Tuesday at 9:30am in the CAI Seminar Room, entry via CAI main doors, facing Wep Harris oval (see map).

If you would like weekly email notification for the seminar series or are interested in presenting, please contact Dr Lorine Wilkinson.