Optoacoustic imaging is able to detect, track and monitor the behaviour of molecules under physiological conditions, often without the use of a contrast agent. By operating in the near-infrared spectral region, the technique provides a direct means of interrogating relevant particle behaviour in living subjects and provides clear and quantitative insight into how their chemophysical properties affect biodistribution, accumulation and pharmacokinetics.

Capabilities:

• Highly sensitive, multiplexed imaging of biological processes with improved spatial resolution over traditional optical imaging (down to 150 µm)

• Direct differentiation between oxygenated and de-oxygenated haemoglobin, real-time analysis of tumour microenvironment

• Analyse tissue heterogeneity directly through quantitation of hypoxia, for example, in tumour tissue

• Observation of growth of some tumours through monitoring of endogenous molecules

For more information about this instrument, please contact the Facility Manager.