Optoacoustic imaging is able to detect, track and monitor the behaviour of molecules under physiological conditions, often without the use of a contrast agent. By operating in the near-infrared spectral region, the technique provides a direct means of interrogating relevant particle behaviour in living subjects and provides clear and quantitative insight into how their chemophysical properties affect biodistribution, accumulation and pharmacokinetics.

Our multispectral optoacoustic imaging iThera MSOT inVision 256-TF system offers unique imaging capabilities, combining tomographic acoustic imaging with optical sensitivity. The exquisite spectral resolution offered by this instrument provides a powerful methodology for elucidating the presence of both endogenous and exogenous probes.

Capabilities include:

  • Single wavelength optoacoustic imaging at 10 Hz
  • Real-time spectral component visualisation
  • Penetration depth of up to 2–4 cm facilitating enhanced whole animal imaging
  • Cross-sectional in-plane resolution of 150 µm
  • Tomographic ultrasound detector array with 256 elements
  • Rapid processing of temporal and spectral elements in imaging experiments

For more information about this instrument, please contact the Facility Manager.
 

Optoacoustic image of gold nanoparticles surface coated with a polymer
(highlighted green), imaged by the CAI Thurecht Group.