Neurodegenerative diseases and the associated cognitive decline of brain functions affect the daily life of many patients. The diagnosis of neurodegenerative diseases is based on symptoms, but neurodegenerative processes start long before symptoms occur. Most of the works have been carried out to identify the biomarkers of neurodegenerative diseases based on volumetric changes of brain regions, but a biomarker to early detect a neurodegenerative disease has not yet been identified. We therefore work on the development of quantitative MRI parameters sensitive to tissue changes (volume, susceptibility, T2*, T1) which could be used as biomarkers before symptoms occur. Changes in iron and myelin alter these quantitative parameters and this research will try to establish a robust relationship between tissue and MRI parameters in a longitudinal setting. The long-term aim is the identification of novel biomarkers in neurodegenerative diseases in single individuals. PhD student Kiran Thapaliya.

Project members

Professor Markus Barth

ARC Future Fellow, Head of Ultra-high Field MR Research
Centre for Advanced Imaging

Dr Steffen Bollmann

National Imaging Facility (NIF) Fellow & UQ Postdoctoral Research Fellow (ultra-high field human imaging)
Centre for Advanced Imaging