This study investigates neurodegeneration and repair of spinal cord injury after traumatic injury using animal models. Potential drug treatments such as EPhA4 have been tested using rat models to improving the recovery after spinal cord injury. In collaboration with Dr Marc Ruitenberg (SBMS).

Key publications:

  • Brennan FH, Cowin GJ, Kurniawan ND, Ruitenberg MJ. Longitudinal assessment of white matter pathology in the injured mouse spinal cord through ultra-high field (16.4 T) in vivo diffusion tensor imaging. NeuroImage. 2013 Nov 15;82:574-85. doi: 10.1089/neu.2012.2729
  • Spanevello MD, Tajouri SI, Mirciov C, Kurniawan N, Pearse MJ, Fabri LJ, Owczarek CM, Hardy MP, Bradford RA, Ramunno ML, Turnley AM, Ruitenberg MJ, Boyd AW, Bartlett PF. Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats. J Neurotrauma. 2013 Jun 15;30(12):1023-34. doi: 10.1002/nbm.2829
  • Blomster LV, Cowin GJ, Kurniawan ND, Ruitenberg MJ. Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolution ex vivo and in vivo MRI. NMR Biomed. 2013 Feb;26(2):141-50. doi: 10.1016/j.neuroimage.2011.06.003
  • Harrison M, O'Brien A, Adams L, Cowin G, Ruitenberg MJ, Sengul G, Watson C. Vertebral landmarks for the identification of spinal cord segments in the mouse. NeuroImage. 2013 Mar;68:22-9. doi: 10.1016/j.neuroimage.2012.11.048.

Project members

Dr Gary Cowin

NIF Facility Fellow and Animal Imaging Facility Manager
Centre for Advanced Imaging

Dr Nyoman Kurniawan

Research Fellow and Microimaging Facility Manager
Centre for Advanced Imaging