Recent work in the group of Dr Mobli has identified the binding site of the essential transcription factor NusA on RNA Polymerase. With the growing problem of antibiotic resistance this research has the potential to provide an alternative target for antibacterial development. Current efforts are aimed at lead identification and development of molecules that inhibit the activity of NusA as well as developing high resolution models of the key interactions that can be used for structure based lead optimisation.

Project members

Associate Professor Mehdi Mobli

UQ Development Fellow
The Centre for Advanced Imaging

Dr Xinying (Sid) Jia

UQ Postdoctoral Research Fellow
The Centre for Advanced Imaging