Ageing and Degenerative Disorders
This programme investigates how ageing and neurodegeneration affect the functional and structural connectivity in the underlying brain networks. Ageing is the biggest risk factor for the development of neurodegenerative diseases, which lead to progressive deterioration of the brain and consequent death. Using multimodal imaging (sMRI, fMRI, rs-MRI, DWI) and complex analytical methods, we examine critical structural and functional biomarkers that predispose healthy older adults to the pathogenesis of specific neurodegenerative diseases, such as Alzheimer’s or Parkinson’s disease. Our ultimate goal is to understand the mechanisms that are responsible for the underlying neuronal dysfunction, in order to improve current diagnostic and therapeutic methods.