This research aims to develop diagnostic imaging tools to study spinal cord anatomy and function using high-resolution structural, spectroscopy, diffusion and functional MRI. Such measurements are used to measure tissue damage, atrophy, white and grey matter integrity, white matter connectivity, and function. New multimodal imaging tools using PET tracers are also being developed to detect inflammatory cells and pain. These imaging tools are crucial for measuring the evaluation of the diseases and testing the efficacy of potential interventions in animal models and clinical translation in patient treatment.