Fluorine-18 for Labeling Small Molecules to Large Molecules for In Vivo PET Imaging
Dr Muneer Ahamed,
Postdoctoral Research Fellow (Thurecht Group), Centre for Advanced Imaging and
Centre for Innovation in Biomedical Imaging Technology (CIBIT)
The University of Queensland, presents:
Fluorine-18 for Labeling Small Molecules to Large Molecules for In Vivo PET Imaging
Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET) in both clinical and preclinical research. Its physical and nuclear characteristics (97% β+ decay, 109.7 min half-life, 635 keV positron energy), along with ease of large scale production (~370 GBq/batch) with high specific activity, make it an attractive nuclide for radiochemical labeling and molecular imaging. The first part of this lecture will deal with development of 18F-labeled small molecule for imaging brain cannabinoid 2 receptor (CB2R), with emphasis to imaging neuroinflammation. The second part will discuss new methods for 18F-labeling of peptides and biomolecules.
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