Associate Professor Greg Pierens
PhD
Interim Academic Director and Operational Manager, NMR Spectroscopy Central Research Platform
Centre for Advanced Imaging
+61 7 334 60347
Researcher biography
Greg Pierens manages the Queensland NMR Network (QNN) 500, 700 & 900 MHz NMR facilities. Greg has extensive experience with NMR spectroscopy working in many different research areas, e.g. NMR / MRI applications to the oil industry, peptide NMR, organic and natural product chemistry. His main research area is in structural elucidation of organic compounds and natural products. He has experience in high throughput NMR for applications such as sample profiling and metabolomics.
Other research interests are in molecular modelling (molecular mechanics and density functional theory) to aid in the interpretation of the experimental NMR data.
Please contact Greg for training to operate the NMR spectrometers and advice on how high resolution NMR spectroscopy can help in your research projects.
View a list of publications on Greg Pierens’s UQ eSpace profile.
Journal Articles
Forster, Louise C., Pierens, Gregory K., De Voss, James J. and Garson, Mary J. (2024). Structural diversity in nudibranch chemistry: elucidation of norditerpenes with a dendrillane scaffold from the Australian nudibranch Goniobranchus coi. Australian Journal of Chemistry, 77 (7) CH24073. doi: 10.1071/ch24073
Coe, Laura J., Zhao, Yongwei, Padva, Leo, Keto, Angus, Schittenhelm, Ralf, Tailhades, Julien, Pierens, Greg, Krenske, Elizabeth H., Crüsemann, Max, De Voss, James and Cryle, Max J. (2024). Reassignment of the structure of a tryptophan‐containing cyclic tripeptide produced by the biarylitide crosslinking cytochrome P450blt. Chemistry: A European Journal, 30 (38) e202400988. doi: 10.1002/chem.202400988
Zeng, Xiangkang, Wang, Tianyi, Wang, Zhuyuan, Tebyetekerwa, Mike, Liu, Yue, Liu, Zhuoyue, Wang, Gen, Wibowo, Ary Anggara, Pierens, Gregory, Gu, Qinfen and Zhang, Xiwang (2024). Fast photocatalytic hydrogen peroxide generation by singlet oxygen-engaged sequential excitation energy and electron-transfer process. ACS Catalysis, 14 (13), 9955-9968. doi: 10.1021/acscatal.4c01591
Su, Chuyi, Dallaston, Madeleine A., Watson, Renée D., Fahrenhorst-Jones, Tyler, Cameron, Jacob P., Pierens, Gregory K., Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2024). The (±)-5-Aza[1.0]triblattane Skeleton via Azetine Cycloaddition. Organic Letters, 26 (14), 2827-2831. doi: 10.1021/acs.orglett.3c03655
Loughlin, Wendy A., Jenkins, Ian D., Healy, Peter C., Karis, N. David and Pierens, Gregory K. (2024). The curious case of the colored crystals of N-substituted 2-oxo-1,2-dihydropyridinyl-3-yl amines and amides: Self-association in the solid state. Journal of Physical Organic Chemistry, 37 (5). doi: 10.1002/poc.4603
Mint, Kelly, Morrow, Joshua P., Warne, Nicole M., He, Xie, Pizzi, David, Shah, Shaffiq Zainal Osman, Pierens, Gregory K., Fletcher, Nicholas L., Bell, Craig A., Thurecht, Kristofer J. and Kempe, Kristian (2024). Comparison of the hydrophilicity of water-soluble poly(2-alkyl-2-oxazoline)s, poly(2-alkyl-2-oxazine)s and poly(2,4-dialkyl-2-oxazoline)s. Polymer Chemistry, 15 (26), 2662-2676. doi: 10.1039/d4py00332b
Summersgill, Matthew D., Gahan, Lawrence R., Chow, Sharon, Pierens, Gregory K., Bernhardt, Paul V., Krenske, Elizabeth H. and Williams, Craig M. (2024). Hyperstable alkenes: are they remarkably unreactive?. Chemical Science. doi: 10.1039/d4sc06697a
Kong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333
Tamuli, Roktima, Nguyen, Thanh, Macdonald, Jacinta R., Pierens, Gregory K., Fisher, Gillian M., Andrews, Katherine T., Adewoyin, Francis B., Omisore, Nusrat O., Odaibo, Alexander B. and Feng, Yunjiang (2023). Isolation and in vitro and in vivo activity of secondary metabolites from clerodendrum polycephalum baker against Plasmodium malaria parasites. Journal of Natural Products, 86 (12), 2661-2671. doi: 10.1021/acs.jnatprod.3c00743
Fahrenhorst-Jones, Tyler, Marshall, David L., Burns, Jed M., Pierens, Gregory K., Van Meurs, Derek P., Kong, Dehui, Bernhardt, Paul V., Blanksby, Stephen J., Savage, G. Paul, Eaton, Philip E. and Williams, Craig M. (2023). 9-Azahomocubane. Chemistry: A European Journal, 30 (3) e202303133, e202303133. doi: 10.1002/chem.202303133
See, Nicholas W., Pierens, Gregory K., Krenske, Elizabeth and Ferro, Vito (2023). C-5 epimerisation of D-mannopyranosyl fluorides: the influence of anomeric configuration on radical reactivity. Synthesis, 56 (06), 966-974. doi: 10.1055/a-2149-4586
Fahrenhorst-Jones, Tyler, Kong, Dehui, Burns, Jed M., Pierens, Gregory K., Bernhardt, Paul V., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid–Amide Bond Comparison to Proline. The Journal of Organic Chemistry, 88 (18), 12867-12871. doi: 10.1021/acs.joc.3c01264
Fahrenhorst-Jones, Tyler, Marshall, David L., Burns, Jed. M., Pierens, Gregory K., Hormann, Robert E., Fisher, Allison M., Bernhardt, Paul V., Blanksby, Stephen J., Savage, G. Paul, Eaton, Philip E. and Williams, Craig M. (2023). 1-azahomocubane. Chemical Science, 14 (11), 2821-2825. doi: 10.1039/d3sc00001j
Adams, Zoë C., Silvestri, Anthony P., Chiorean, Sorina, Flood, Dillon T., Balo, Brian P., Shi, Yifan, Holcomb, Matthew, Walsh, Shawn I., Maillie, Colleen A., Pierens, Gregory K., Forli, Stefano, Rosengren, K. Johan and Dawson, Philip E. (2023). Stretching peptides to generate small molecule β-strand mimics. ACS Central Science, 9 (4), 648-656. doi: 10.1021/acscentsci.2c01462
Miao, William Gang, Nguyen, Thanh, Iqbal, Jamila, Pierens, Gregory K., Ma, Linlin, Richardson, Des R., Wood, Stephen A., Mellick, George D., Quinn, Ronald J. and Feng, Yunjiang (2022). Meeting the Challenge 2: identification of potential chemical probes for Parkinson's Disease from Ligusticum chuanxiong hort using cytological profiling. ACS Chemical Neuroscience, 13 (17), 2565-2578. doi: 10.1021/acschemneuro.1c00820
Narbutas, Patrick T., Pierens, Gregory K., Clegg, Jack K. and Garson, Mary J. (2021). Oxygenated sesquiterpenes from the Indo-Pacific nudibranch Ardeadoris rubroannulata: structure revision of pu’ulenal. Natural Product Communications, 16 (10), 1934578X2110550. doi: 10.1177/1934578x211055025
Pierens, Gregory K. (2021). A new metric for evaluating DFT calculated proton and carbon chemical shifts of natural products and organic compounds. ChemPhysChem, 22 (21), 2207-2214. doi: 10.1002/cphc.202100579
Lim, Ting Xiang, Pierens, Gregory K., Bernhardt, Paul V., Ahamed, Muneer and Reutens, David C. (2021). Synthesis, isolation and characterisation of fluorinated‐benzimidazoisoquinoline regioisomers. Magnetic Resonance in Chemistry, 59 (11) mrc.5193, 1154-1159. doi: 10.1002/mrc.5193
Zhang, Jiayu, Nguyen, Duy Thanh, Pierens, Gregory K., Cock, Ian and Feng, Yunjiang (2021). Austrobuxusin N, a new picrotoxane terpenoid glycoside, from the Australian endemic plant Austrobuxus swainii (Beuzev. & C.T. White) Airy Shaw. Natural Product Research, 36 (20), 1-7. doi: 10.1080/14786419.2021.1923710
Currin-Ross, Denni, Husdell, Luke, Pierens, Gregory K., Mok, Nicholas E., O'Neill, Scott L., Schirra, Horst Joachim and Brownlie, Jeremy C. (2021). The metabolic response to infection with Wolbachia implicates the insulin/insulin-like-growth factor and hypoxia signaling pathways in Drosophila melanogaster. Frontiers in Ecology and Evolution, 9 623561, 1-16. doi: 10.3389/fevo.2021.623561
Nguyen, Duy Thanh, Iqbal, Jamila, Han, Jianying, Pierens, Gregory K., Wood, Stephen A., Mellick, George D. and Feng, Yunjiang (2020). Chemical constituents from Macleaya cordata (Willd) R. Br. and their phenotypic functions against a Parkinson's disease patient-derived cell line. Bioorganic and Medicinal Chemistry, 28 (21) 115732, 1-9. doi: 10.1016/j.bmc.2020.115732
Chow, Sharon, Krainz, Tanja, Bettencourt, Christian J., Broit, Natasa, Ferguson, Blake, Zhu, Mingzhao, Hull, Kenneth G., Pierens, Gregory K., Bernhardt, Paul V., Parsons, Peter G., Romo, Daniel, Boyle, Glen M. and Williams, Craig M. (2020). Synthetic tigliane intermediates engage thiols to induce potent cell line selective anti‐cancer activity. Chemistry: A European Journal, 26 (59) chem.202003221, 13372-13377. doi: 10.1002/chem.202003221
Narbutas, Patrick T., Clegg, Jack K., Pierens, Gregory K., Cheney, Karen L., Ganderton, Anna M. and Garson, Mary J. (2020). Arenaran sesquiterpenes from the nudibranch Chromodoris strigata and its dietary sponge Acanthodendrilla sp. 2510: spectroscopic and computational studies. Australian Journal of Chemistry, 73 (10), 948-955. doi: 10.1071/ch19540
Forster, Louise C., Pierens, Gregory K., Clegg, Jack K. and Garson, Mary J. (2020). Dynamic NMR and computational studies inform the conformational description of dendrillane terpenes from the nudibranch Goniobranchus coi. Journal of Natural Products, 83 (3) acs.jnatprod.9b01051, 714-719. doi: 10.1021/acs.jnatprod.9b01051
Venkatachalam, T.K., Stimson, D.H.R., Frisch, K., Pierens, G.K., Bhalla, R. and Reutens, D.C. (2019). Radiolabeling of protected tryptophan with [18F]fluoromethyl tosylate: Formation of [18F]fluoromethyl ester of tryptophan instead of 1-N-[18F]fluoromethyl tryptophan methylester. Applied Radiation and Isotopes, 152, 172-179. doi: 10.1016/j.apradiso.2019.06.039
Sim, Desmond C.-M., Hungerford, Natasha L., Krenske, Elizabeth H., Pierens, Gregory K., Andrews, Katherine T., Skinner-Adams, Tina S. and Garson, Mary J. (2019). A sesquiterpene isonitrile with a new tricyclic skeleton from the Indo-Pacific nudibranch Phyllidiella pustulosa: Spectroscopic and computational studies. Australian Journal of Chemistry, 73 (3), 129-136. doi: 10.1071/CH19227
Forster, Louise C., Pierens, Gregory K. and Garson, Mary J. (2019). Elucidation of relative and absolute configurations of highly rearranged diterpenoids and evidence for a putative biosynthetic intermediate from the Australian nudibranch Goniobranchus geometricus. Journal of Natural Products, 82 (3) acs.jnatprod.8b00713, 449-455. doi: 10.1021/acs.jnatprod.8b00713
Venkatachalam, Taracad K., Bernhardt, Paul V., Pierens, Gregory K., Stimson, Damion H. R., Bhalla, Rajiv and Reutens, David C. (2019). Synthesis and characterisation of indium(iii) bis-thiosemicarbazone complexes: 18 F incorporation for PET imaging. Australian Journal of Chemistry, 72 (5), 383-391. doi: 10.1071/CH18559
Hoffmann, Reinhard W., Schmalz, Hans-Günther, Koert, Ulrich and Pierens, Gregory K. (2019). Comment on Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: determination of the absolute configurations of the latter two alkaloids by B. Chen, X. Liu, Y.-J. Hu, D.-M. Zhang, L. Deng, J. Lu, L. Min, W.-C. Ye and C.-C. Li, Chem. Sci., 2017, 8, 4961–4966. Chemical Science, 10 (3), 943-945. doi: 10.1039/c8sc90247j
Brinson, Robert G., Marino, John P., Delaglio, Frank, Arbogast, Luke W., Evans, Ryan M., Kearsley, Anthony, Gingras, Geneviève, Ghasriani, Houman, Aubin, Yves, Pierens, Gregory K., Jia, Xinying, Mobli, Mehdi, Grant, Hamish G., Keizer, David W., Schweimer, Kristian, Ståhle, Jonas, Widmalm, Göran, Zartler, Edward R., Lawrence, Chad W., Reardon, Patrick N., Cort, John R., Xu, Ping, Ni, Feng, Yanaka, Saeko, Kato, Koichi, Parnham, Stuart R., Tsao, Desiree, Blomgren, Andreas, Rundlöf, Torgny ... Wikström, Mats (2019). Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics. mAbs, 11 (1), 94-105. doi: 10.1080/19420862.2018.1544454
White, A. M., Dao, K., Vrubliauskas, D., Konst, Z. A., Pierens, G. K., Mándi, A., Andrews, K. T., Skinner-Adams, T. S., Clarke, M. E., Narbutas, P. T., Sim, D. C.-M., Cheney, K. L., Kurtán, T., Garson, M. J. and Vanderwal, C. D. (2018). Correction to catalyst-controlled stereoselective synthesis secures the structure of the antimalarial isocyanoterpene pustulosaisonitrile-1. The Journal of Organic Chemistry, 83 (16), 9571-9572. doi: 10.1021/acs.joc.8b01819
Frisch, Kim, Stimson, Damion H. R., Venkatachalam, Taracad, Pierens, Gregory K., Keiding, Susanne, Reutens, David and Bhalla, Rajiv (2018). N-(4-[18F]fluorobenzyl)cholylglycine, a novel tracer for PET of enterohepatic circulation of bile acids: radiosynthesis and proof-of-concept studies in rats. Nuclear Medicine and Biology, 61, 56-62. doi: 10.1016/j.nucmedbio.2018.04.004
Lonhienne, Thierry, Garcia, Mario D., Pierens, Gregory, Mobli, Mehdi, Nouwens, Amanda and Guddat, Luke W. (2018). Structural insights into the mechanism of inhibition of AHAS by herbicides. Proceedings of the National Academy of Sciences of the United States of America, 115 (9), E1945-E1954. doi: 10.1073/pnas.1714392115
Dewi, Ariyanti S., Pierens, Gregory K., Cheney, Karen L., Blanchfield, Joanne T. and Garson, Mary J. (2018). Chromolactol, an Oxygenated Diterpene from the Indo-Pacific Nudibranch Goniobranchus coi: Spectroscopic and Computational Studies. Australian Journal of Chemistry, 71 (10), 798-803. doi: 10.1071/CH18243
Venkatachalam, T. K., Bernhardt, Paul V., Pierens, G. K. and Reutens, D. C. (2018). NMR, X-Ray Crystal Structure Studies and Mechanism for Formation of a Novel Di-gallium Complex and 5-Methoxy-4,5,6-triphenyl-4,5-dihydro-1,2,4-triazene-3(2H)-thione. Journal of Chemical Crystallography, 49 (3), 131-138. doi: 10.1007/s10870-018-0745-z
Pierens, Gregory K., Venkatachalam, T. K. and Reutens, David C. (2017). NMR and DFT investigations of structure of colchicine in various solvents including density functional theory calculations. Scientific Reports, 7 (1) 5605, 5605.1-5605.9. doi: 10.1038/s41598-017-06005-5
Macabeo, Allan Patrick G, Letada, Arianne G, Budde, Simon, Faderl, Christian, Dahse, Hans-Martin, Franzblau, Scott G, Alejandro, Grecebio Jonathan D, Pierens, Gregory K and Garson, Mary J (2017). Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba. Journal of natural products, 80 (12), 3319-3323. doi: 10.1021/acs.jnatprod.7b00679
Keough, Dianne T., Rejman, Dominik, Pohl, Radek, Zborníková, Eva, Hocková, Dana, Croll, Tristan, Edstein, Michael D., Birrell, Geoff W., Chavchich, Marina, Naesens, Lieve M. J., Pierens, Gregory K., Brereton, Ian M. and Guddat, Luke W. (2017). Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chemical Biology, 13 (1), 82-90. doi: 10.1021/acschembio.7b00916
White, Andrew M., Dao, Kathy, Vrubliauskas, Darius, Könst, Zef A., Pierens, Gregory K., Mándi, Attila, Andrews, Katherine T., Skinner-Adams, Tina S., Clarke, Mary E., Narbutas, Patrick T., Sim, Desmond C.-M., Cheney, Karen L., Kurtán, Tibor, Garson, Mary J. and Vanderwal, Christopher D. (2017). Catalyst-Controlled Stereoselective Synthesis Secures the Structure of the Antimalarial Isocyanoterpene Pustulosaisonitrile-1. Journal of Organic Chemistry, 82 (24) acs.joc.8b01819, 13313-13323. doi: 10.1021/acs.joc.7b02421
Venkatachalam, T K, Stimson, D H R, Pierens, G K, Bhalla, R and Reutens, D C (2017). Challenges in the automated synthesis of [(18)F]-1-fluoroethyl tryptophan: Formation of both O- and N-alkylated products. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 131, 41-48. doi: 10.1016/j.apradiso.2017.10.047
Venkatachalam, Taracad K., Bernhardt, Paul V., Stimson, Damion H. R., Pierens, Gregory K., Bhalla, Rajiv and Reutens, David C. (2017). A Novel Strategy to Introduce 18F, a Positron Emitting Radionuclide, into a Gallium Nitrate Complex: Synthesis, NMR, X-Ray Crystal Structure, and Preliminary Studies on Radiolabelling with 18F. Australian Journal of Chemistry, 71 (3), 81-86. doi: 10.1071/CH17334
Zhang, Benyin, Tian, Wenya, Wang, Shuwen, Yan, Xiaoli, Jia, Xinying, Pierens, Gregory K., Chen, Wenqing, Ma, Hongmin, Deng, Zixin and Qu, Xudong (2017). Activation of natural products biosynthetic pathways via a protein modification level regulation. ACS Chemical Biology, 12 (7), 1732-1736. doi: 10.1021/acschembio.7b00225
Forster, Louise C., Pierens, Gregory K., White, Andrew M., Cheney, Karen L., Dewapriya, Pradeep, Capon, Robert J. and Garson, Mary J. (2017). Cytotoxic spiroepoxide lactone and its putative biosynthetic precursor from Goniobranchus Splendidus. ACS Omega, 2 (6), 2672-2677. doi: 10.1021/acsomega.7b00641
Venkatachalam, T. K., Bernhardt, P. V., Pierens, G. K. and Reutens, D. C. (2017). Synthesis and X-ray Crystal Structure of 2 and 4-Trifluoromethyl Substituted Phenyl Semicarbazone and Thiosemicarbazone. Journal of Chemical Crystallography, 47 (1), 30-39. doi: 10.1007/s10870-017-0677-z
Garson, Mary J., Hehre, Warren , Pierens, Gregory K. and Suciati (2017). Revision of the structure of acremine P from a marine-derived strain of Acremonium persicinum. Molecules, 22 (4) 521, 521. doi: 10.3390/molecules22040521
Roberts, Matthew J., Hattwell, Jake P. N., Chow, Clement W. K., Lavin, Martin, Pierens, Gregory K., Gardiner, Robert A. and Schirra, Horst Joachim (2016). Tartrate inhibition of prostatic acid phosphatase improves seminal fluid metabolite stability. Metabolomics, 12 (11) 162, 162.1-162.14. doi: 10.1007/s11306-016-1102-x
Venkatachalam, T. K., Pierens, G. K., Bernhardt, Paul. V., Stimson, D. H. R., Bhalla, R., Lambert, L. and Reutens, D. C. (2016). Heteronuclear NMR spectroscopic investigations of gallium complexes of substituted thiosemicarbazones including x-ray crystal structure, a new halogen exchange strategy, and 18F radiolabelling. Australian Journal of Chemistry, 69 (9), 1033-1048. doi: 10.1071/CH16044
Pierens, Gregory K., Venkatachalam, Taracad K. and Reutens, David C. (2016). Investigation of two- and three-bond carbon-hydrogen coupling constants in cinnamic acid based compounds. Magnetic Resonance in Chemistry, 54 (12), 941-946. doi: 10.1002/mrc.4469
Khokhar, Shahan, Pierens, Gregory K., Hooper, John N. A., Ekins, Merrick G., Feng, Yunjiang and Davis, Rohan A. (2016). Rhodocomatulin-type anthraquinones from the Australian marine invertebrates Clathria hirsuta and Comatula rotalaria. Journal of Natural Products, 79 (4), 946-953. doi: 10.1021/acs.jnatprod.5b01029
Venkatachalam, Taracad K., Bernhardt, Paul V., Noble, Chris J., Fletcher, Nicholas, Pierens, Gregory K., Thurecht, Kris J. and Reutens, David C. (2016). Synthesis, characterization and biological activities of semicarbazones and their copper complexes. Journal of Inorganic Biochemistry, 162, 295-308. doi: 10.1016/j.jinorgbio.2016.04.006
White, Andrew M., Pierens, Gregory K., Forster, Louise C., Winters, Anne E., Cheney, Karen L. and Garson, Mary J. (2015). Rearranged Diterpenes and Norditerpenes from Three Australian Goniobranchus Mollusks.. Journal of Natural Products, 79 (3), 477-483. doi: 10.1021/acs.jnatprod.5b00866
Pierens, Gregory K., Venkatachalam, T. K. and Reutens, David C. (2015). Comparison of experimental and DFT-calculated NMR chemical shifts of 2-amino and 2-hydroxyl substituted phenyl benzimidazoles, benzoxazoles and benzothiazoles in four solvents using the IEF-PCM solvation model.. Magnetic Resonance in Chemistry, 54 (4), 298-307. doi: 10.1002/mrc.4374
Hirayama, Yuichiro, Katavic, Peter L., White, Andrew M., Pierens, Gregory K., Lambert, Lynette K., Winters, Anne E., Kigoshi, Hideo, Kita, Masaki and Garson, Mary J. (2015). New Cytotoxic Norditerpenes from the Australian Nudibranchs Goniobranchus Splendidus and Goniobranchus Daphne. Australian Journal of Chemistry, 69 (2), 136-144. doi: 10.1071/CH15203
White, Andrew M., Pierens, Gregory K., Skinner-Adams, Tina, Andrews, Katherine T., Bernhardt, Paul V., Krenske, Elizabeth H., Mollo, Ernesto and Garson, Mary J. (2015). Antimalarial isocyano and isothiocyanato sesquiterpenes with tri- and bicyclic skeletons from the nudibranch Phyllidia ocellata. Journal of Natural Products, 78 (6), 1422-1427. doi: 10.1021/acs.jnatprod.5b00354
Venkatachalam, T. K., Pierens, G. K., Bernhardt, P. V. and Reutens, D. C. (2015). Heteronuclear NMR spectroscopic investigations of hydrogen bonding in 2-(benzo[d]thiazole-2'-yl)-N-alkylanilines. Magnetic Resonance in Chemistry, 53 (6), 448-453. doi: 10.1002/mrc.4228
Pierens, Gregory K. (2014). 1H and 13C NMR scaling factors for the calculation of chemical shifts in commonly used solvents using density functional theory. Journal of Computational Chemistry, 35 (18), 1388-1394. doi: 10.1002/jcc.23638
Venkatachalam, T. K., Stimson, D. H. R., Bhalla, R., Pierens, G. K. and Reutens, D. C. (2014). Synthesis, characterization and 11C radiolabeling of aminophenyl benzothiazoles:structural effects on the alkylation of amino group. Journal of Labelled Compounds and Radiopharmaceuticals, 57 (9), 566-573. doi: 10.1002/jlcr.3216
Pierens, G. K., Venkatachalam, T. K. and Reutens, D. (2014). A comparative study between para-aminophenyl and ortho-aminophenyl benzothiazoles using NMR and DFT calculations. Magnetic Resonance in Chemistry, 52 (8), 453-459. doi: 10.1002/mrc.4088
Venkatachalam, T. K., Pierens, Gregory K. and Reutens, David C. (2014). Synthesis, NMR structural characterization and molecular modeling of substituted thiosemicarbazones and semicarbazones using DFT calculations to prove the syn/anti isomer formation. Magnetic Resonance in Chemistry, 52 (3), 98-105. doi: 10.1002/mrc.4041
Suciati, Fraser, James A., Lambert, Lynette K., Pierens, Gregory K., Bernhardt, Paul V. and Garson, Mary J. (2013). Secondary metabolites of the sponge-derived fungus Acremonium persicinum. Journal of Natural Products, 76 (8), 1432-1440. doi: 10.1021/np4002114
Pierens, Gregory K., Brossi, Steven, Yang, Zhengyi, Reutens, David C. and Vegh, Viktor (2012). HSQC spectral based similarity matching of compounds using nearest neighbours and a fast discrete genetic algorithm. Journal of Cheminformatics, 4 (10) 25, 25.1-25.8. doi: 10.1186/1758-2946-4-25
Somerville, Michael J., Katavic, Peter L., Lambert, Lynette K., Pierens, Gregory K., Blanchfield, Joanne T., Cimino, Guido, Mollo, Ernesto, Gavagnin, Margherita, Banwell, Martin G. and Garson, Mary J. (2012). Isolation of thuridillins D−F, diterpene metabolites from the Australian sacoglossan mollusk Thuridilla splendens; relative configuration of the epoxylactone ring. Journal of Natural Products, 75 (9), 1618-1624. doi: 10.1021/np300442s
Pierens, Gregory K., Venkatachalam, T. K., Bernhardt, Paul V., Riley, Mark J. and Reutens, David C. (2012). A solid state study of keto-enol tautomerismin in three naphthaledene Schiff bases. Australian Journal of Chemistry, 65 (5), 552-556. doi: 10.1071/CH12122
Venkatachalam, T. K., Pierens, Gregory K., Bernhardt, Paul V., Hammond, Luke and Reutens, David C. (2011). Synthesis and structural characterization of (Z)-3-[(4-chlorophenylamino) methylene] naphthalene-2(3H)-one: An enol, keto or zwitterionic tautomer?. Journal of Chemical Crystallography, 41 (7), 944-951. doi: 10.1007/s10870-011-0022-x
Suciati, Garson, Mary J., Bernhardt, Paul V. and Pierens, Gregory K. (2011). A new N,N-dimethyl purine from an Australian dictyoceratid sponge. Journal of Chemical Crystallography, 41 (11), 1669-1672. doi: 10.1007/s10870-011-0155-y
Venkatachalam, T. K., Pierens, G. K., Bernhardt, P. V. and Reutens, D. C. (2011). Synthesis and x-ray crystal structure of 1- and 2-cinnamoyaloxy acetonaphthones. Journal of Chemical Crystallography, 41 (4), 563-569. doi: 10.1007/s10870-010-9923-3
Vegh, Viktor, Pierens, Gregory K. and Tieng, Quang M. (2011). A variant of differential evolution for discrete optimization problems requiring mutually distinct parameters. International Journal of Innovative Computing, Information and Control, 7 (2), 897-914.
Venkatachalam, T. K., Pierens, G. K. and Reutens, D. C. (2010). Synthesis and characterization of oxazolopyridine and benzoxazole derivatives. Letters in Organic Chemistry, 7 (7), 519-527. doi: 10.2174/157017810793362352
Venkatachalam, TK, Pierens, GK and Reutens, DC (2010). Synthesis and characterization of 1-and 2-cinnamoyloxyacetonaphthones. Magnetic Resonance in Chemistry, 48 (10), 804-810. doi: 10.1002/mrc.2668
Venkatachalam, TK, Pierens, GK and Reutens, D (2010). Synthesis and characterization of anils exhibiting thermochromism. Australian Journal of Chemistry, 63 (8), 1272-1282. doi: 10.1071/CH09579
Venkatachalam, Taracad K., Pierens, Gregory K., Campitelli, Mary R. and Reutens, David C. (2010). Structural investigation on phenyl- and pyridin-2-ylamino(methylene)naphthalen-2(3H)-one. Substituent effects on the NMR chemical shifts. Magnetic Resonance in Chemistry, 48 (8), 585-592. doi: 10.1002/mrc.2626
Venkatachalam, T. K., Pierens, G. K. and Reutens, D. C. (2010). Synthesis and characterization of benzothiazolyl substituted anils (vol 48, pg 210-218, 2010). Magnetic Resonance in Chemistry, 48 (4), 331-331. doi: 10.1002/mrc.2591
Venkatachalam, Taracad K., Pierens, Gregory K. and Reutens, David C. (2010). Synthesis and characterization of benzothiazolyl-substituted anils. Magnetic Resonance in Chemistry, 48 (3), 210-218. doi: 10.1002/mrc.2568
Graham, SK, Lambert, LK, Pierens, GK, Hooper, JNA and Garson, MJ (2010). Psammaplin metabolites new and old: An NMR study involving chiral sulfur chemistry. Australian Journal of Chemistry, 63 (6), 867-872. doi: 10.1071/CH09617
Mobli, M., Dantas de Araujo, A., Lambert, L. K., Pierens, G. K., Windley, M. J., Nicholson, G. M., Alewood, P. F. and King, G. E. (2009). Direct Visualization of Disulfide Bonds through Diselenide Proxies Using Se-77 NMR Spectroscopy. Angewandte Chemie International Edition, 48 (49), 9312-9314. doi: 10.1002/anie.200905206
Pierens, G. K., Mobli, M. and Vegh, V. (2009). Effective Protocol for Database Similarity Searching of Heteronuclear Single Quantum Coherence Spectra. Analytical Chemistry, 81 (22), 9329-9335. doi: 10.1021/ac901616t
Schweiker, Stephanie S., Loughlin, Wendy A., Brown, Christopher L. and Pierens, Gregory K. (2009). Synthesis of new modified truncated peptides and inhibition of glycogen phosphorylase. Journal of Peptide Science, 15 (6), 442-450. doi: 10.1002/psc.1140
Quinn, Ronald J., Carroll, Anthony R., Pham, Ngoc B., Baron, Paul, Palframan, Meredeth E., Suraweera, Lekha, Pierens, Gregory K. and Muresan, Sorel (2008). Developing a drug-like natural product library (Journal of Natural Products (2008) 71, (468)). Journal of Natural Products, 71 (10), 1792-1792. doi: 10.1021/np800216b
Pierens, G. K., Carroll, A. R., Davis, R. A., Palframan, M. E. and Quinn, R. J. (2008). Determination of analyte concentration using the residual solvent resonance in H-1 NMR spectroscopy. Journal of Natural Products, 71 (5), 810-813. doi: 10.1021/np8000046
Quinn, Ronald J., Carroll, Anthony R., Pham, Ngoc B., Baron, Paul, Palframan, Meredith E., Suraweera, Lekha., Pierens, Gregory K. and Muresan, Sorel. (2008). Developing a drug-like natural product library. Journal of Natural Products, 71 (3), 464-468. doi: 10.1021/np070526y
Loughlin, W. A., Pierens, G. K., Petersson, M. J., Henderson, L. C. and Healy, P. C. (2008). Evaluation of novel Hyphodermin derivatives as Glycogen Phosphorylase a inhibitors. Bioorganic & Medicinal Chemistry, 16 (11), 6172-6178. doi: 10.1016/j.bmc.2008.04.047
Davis, Rohan A., Pierens, Gregory K. and Parsons, Peter G. (2007). Synthesis and spectroscopic characterisation of a combinatorial library based on the fungal natural product 3-chloro-4-hydroxyphenylacetamide. Magnetic Resonance in Chemistry, 45 (5), 442-445. doi: 10.1002/mrc.1984
Davis, Rohan A. and Pierens, Gregory K. (2006). 1H and 13C NMR assignments for two new xanthones from the endophytic fungus Xylaria sp. FRR 5657. Magnetic Resonance in Chemistry, 44 (10), 966-968. doi: 10.1002/mrc.1872
Rochfort, Simone J., Towerzey, Leanne, Carroll, Anthony, King, Gordon, Michael, Adam, Pierens, Greg, Rali, Topul, Redburn, Joanne, Whitmore, Jaqueline and Quinn, Ronald J. (2005). Latifolians A and B, Novel JNK3 Kinase Inhibitors from the Papua New Guinean Plant Gnetum latifolium. Journal of Natural Products, 68 (7), 1080-1082. doi: 10.1021/np049616i
Pierens, Gregory K., Palframan, Meredith E., Tranter, Carolyn J., Carroll, Anthony R. and Quinn, Ronald J. (2005). A robust clustering approach for NMR spectra of natural product extracts. Magnetic Resonance in Chemistry, 43 (5), 359-365. doi: 10.1002/mrc.1562
Ramadan, Saadallah A., Field, Leslie D. and Pierens, Gregory K. (2003). Multiple quantum nuclear magnetic resonance spectra of partially oriented styrene in a nematic phase. Molecular physics, 101 (12), 1813-1818. doi: 10.1080/0026897031000112488
Grice, I. D., Garnham, B., Pierens, G., Rogers, K., Tindal, D. and Griffiths, L. R. (2003). Isolation of two phenylethanoid glycosides from Eremophila gilesii. Journal of Ethnopharmacology, 86 (1), 123-125. doi: 10.1016/S0378-8741(03)00034-5
Carroll, Anthony R., Pierens, Gregory K., Fechner, Greg, de Almeida Leone, Priscila, Ngo, Anna, Simpson, Moana, Hyde, Edward, Hooper, John N. A., Boström, Stig-Lennart, Musil, Djordje and Quinn, Ronald J. (2002). Dysinosin A: A Novel Inhibitor of Factor VIIa and Thrombin from a New Genus and Species of Australian Sponge of the Family Dysideidae. Journal of the American Chemical Society, 124 (45), 13340-13341. doi: 10.1021/ja020814a
Healy, Peter C., Loughlin, Wendy A., McCleary, Michelle A., Pierens, Gregory K. and Rowen, Catherine C. (2002). Structural studies on sulfonylbicyclo[n.2.0]alkan-1-ols. Journal of physical organic chemistry, 15 (11), 733-741. doi: 10.1002/poc.542
Field, Lesley D., Ramadan, Saadallah A. and Pierens, Gregory K. (2002). Multiple-Quantum NMR Spectra of Partially Oriented Indene: A New Approach to Estimating Order in a Nematic Phase. Journal of Magnetic Resonance, 156 (1), 64-71. doi: 10.1006/jmre.2002.2528
Volter, KE, Embrey, KJ, Pierens, GK and Quinn, RJ (2001). A study of the binding requirements of calyculin A and dephosphonocalyculin A with PP1, development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1. European Journal of Pharmaceutical Sciences, 12 (3), 181-194. doi: 10.1016/S0928-0987(00)00116-0
Volter, KE, Pierens, GK, Quinn, RJ, Wakimoto, T, Matsunaga, S and Fusetani, N (1999). The solution structures of calyculin A and dephosphonocalyculin A by NMR.. Bioorganic & Medicinal Chemistry Letters, 9 (5), 717-722. doi: 10.1016/S0960-894X(99)00066-9
Davis, RA, Carroll, AR, Pierens, GK and Quinn, RJ (1999). New lamellarin alkaloids from the Australian ascidian, Didemnum chartaceum. Journal of Natural Products, 62 (3), 419-424. doi: 10.1021/np9803530
Neve, J, Leone, PD, Carroll, AR, Moni, RW, Paczkowski, NJ, Pierens, G, Bjorquist, P, Deinum, J, Ehnebom, J, Inghardt, T, Guymer, G, Grimshaw, P and Quinn, RJ (1999). Sideroxylonal C, a new inhibitor of human plasminogen activator inhibitor type-1, from the flowers of Eucalyptus albens. Journal of Natural Products, 62 (2), 324-326. doi: 10.1021/np980286+
Norris, RL, Pierens, G, Shaw, GR, Smith, MJ, Chiswell, RK, Seawright, AA and Moore, MR (1999). Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii. Environmental Toxicology, 14 (1), 163-165. doi: 10.1002/(SICI)1522-7278(199902)14:1<163::AID-TOX21>3.0.CO;2-V
Wong, AK, Finch, AM, Pierens, GK, Craik, DJ, Taylor, SM and Fairlie, DP (1998). Small molecular probes for G-protein-coupled C5a receptors: Conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a. Journal of Medicinal Chemistry, 41 (18), 3417-3425. doi: 10.1021/jm9800651
Hoffmann, R, Craik, DJ, Pierens, G, Bolger, RE and Otvos, L (1998). Phosphorylation of the C-terminal sites of human p53 reduces non-sequence-specific DNA binding as modeled with synthetic peptides. Biochemistry, 37 (39), 13755-13764. doi: 10.1021/bi980760a
Wong, AK, Finch, AM, Pierens, GK, Taylor, SM and Fairlie, DP (1997). Conformationally constrained small molecule antagonists of C5a.. Abstracts of Papers of The American Chemical Society, 214, 9-MEDI.
Abbenante, G., Fairlie, D. P., Gahan, L. R., Hanson, G. R., Pierens, G. K. and van den Brenk, A. L. (1996). Conformational control by thiazole and oxazoline rings in cyclic octapeptides of marine origin. Novel macrocyclic chair and boat conformations. Journal of the American Chemical Society, 118 (43), 10384-10388. doi: 10.1021/ja962260f
Wang, GS, Pierens, GK, Treleaven, WD, Sparrow, JT and Cushley, RJ (1996). Conformations of human apolipoprotein E(263-286) and E(267-289) in aqueous solutions of sodium dodecyl sulfate by CD and H-1 NMR. Biochemistry, 35 (32), 10358-10366. doi: 10.1021/bi960934t
Peyron, M, Pierens, GK, Lucas, AJ, Hall, LD and Stewart, RC (1996). The modified stretched-exponential model for characterization of NMR relaxation in porous media. Journal of Magnetic Resonance Series a, 118 (2), 214-220. doi: 10.1006/jmra.1996.0029
Pierens, GK, Peyron, M, Lucas, AJ, Carpenter, TA, Hall, LD, Potter, GF, Stewart, RC and Phelps, DW (1994). Quantitative Longitudinal Fluid Saturation Profiles with a Slice-Selected Cpmg Sequence. Magnetic Resonance Imaging, 12 (2), 323-324. doi: 10.1016/0730-725X(94)91547-4
Lucas, AJ, Derbyshire, JA, Dillon, N, Peyron, M, Pierens, GK, Hall, LD, Phelps, DW and Stewart, RC (1994). 3d Autocorrelation for the Determination of Large-Pore Sizes. Magnetic Resonance Imaging, 12 (2), 253-255. doi: 10.1016/0730-725X(94)91530-X
Lucas, AJ, Gibbs, SJ, Peyron, M, Pierens, GK, Hall, LD, Stewart, RC and Phelps, DW (1994). Pore Geometry Information Via Pulsed-Field Gradient Nmr. Magnetic Resonance Imaging, 12 (2), 249-251. doi: 10.1016/0730-725X(94)91529-6
Carpenter, TA, Colebrook, LD, Hall, LD and Pierens, GK (1993). Application of Gradient-Selective Cosy and Double-Quantum Filtered Gradient-Selective Cosy Experiments to Carbohydrates - 2-Deoxy-D-Arabino-Hexose (2-Deoxy-D-Glucose). Carbohydrate Research, 241, 267-272. doi: 10.1016/0008-6215(93)80114-T
Pierens, GK, Carpenter, TA, Colebrook, LD, Field, LD and Hall, LD (1992). Selection of Multiple-Quantum Spectra of Molecules in Liquid-Crystalline Solution Using Pulsed Magnetic-Field Gradients. Journal of Magnetic Resonance, 99 (2), 398-402. doi: 10.1016/0022-2364(92)90193-B
Carpenter, TA, Colebrook, LD, Hall, LD and Pierens, GK (1992). Applications of Gradient-Selective Cosy and Dqcosy to Brucine and Gibberellic-Acid. Magnetic Resonance in Chemistry, 30 (8), 768-773. doi: 10.1002/mrc.1260300813
Field, LD, Pierens, GK, Cross, KJ and Terry, ML (1992). Multiple-Quantum Nmr-Spectroscopy of Molecules Aligned in Liquid-Crystalline Solvents. Journal of Magnetic Resonance, 97 (3), 451-465. doi: 10.1016/0022-2364(92)90027-5
Field, LD, Hambley, TW and Pierens, GK (1991). Structure of 4'-Butyl-2,3,5,6-Tetrafluorobiphenyl-4-Carbonitrile. Acta Crystallographica Section C-Crystal Structure Communications, 47 (3), 632-634. doi: 10.1107/S0108270190008241
Field, LD, Hambley, TW and Pierens, GK (1990). Synthesis and Properties of Partially Fluorinated 4-Alkyl-4'-Cyanobiphenyls .2. 4-Alkyl-4'-Cyano-2',3',5',6'-Tetrafluorobiphenyls. Tetrahedron, 46 (20), 7069-7080. doi: 10.1016/S0040-4020(01)87891-1
Field, LD and Pierens, GK (1990). Synthesis and Properties of Partially Fluorinated 4-Alkyl-4-Cyanobiphenyls .1. 4'-Alkyl-4-Cyano-2',3',5',6'-Tetrafluorobiphenyls. Tetrahedron, 46 (20), 7059-7068. doi: 10.1016/S0040-4020(01)87890-X
Conference Papers
Forster, Louise C., Pierens, Gregory K., Cheney, Karen L. and Garson, Mary J. (2020). Inconspicuous carbon NMR signals and fluxional effects complicate the structural elucidation of Noriterpenes from Goniobranchus coi. XVI International Symposium on Marine Natural Products|XI European Conference on Marine Natural Products, Peniche, Portugal, September 1-5, 2019. Basel, Switzerland: MDPI. doi: 10.3390/md18010040
Stimson, D., Venkatachalam, T. K., Pierens, G. K., Bernhardt, P. V., Mardon, K., Reutens, D. C. and Bhalla, R. (2019). Development of novel [F-18]thiosemicarbazone metal fluoride complexes as potential neuroimaging agents. 32nd Annual Congress of the European Association of Nuclear Medicine (EANM), Barcelona, Spain, 12-16 October 2019. Heidelberg, Germany: Springer.
Frisch, Kim, Stimson, Damion H., Venkatachalam, Taracad, Pierens, Greg, Keiding, Susanne, Reutens, David and Bhalla, Rajiv (2017). Proof-of-Concept for Positron Emission Tomography of the Enterohepatic Circulation of Conjugated Bile Acids in Rats. 68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) / Liver Meeting, Washington DC, 20-24 October 2017 . Hoboken, NJ, United States: John Wiley & Sons.
Yang, Zhengyi, Vegh, Viktor, Reutens, David C. and Pierens, Gregory K. (2011). A rapid procedure for spectral similarity matching of heteronuclear single quantum coherence spectra. 2011 International Conference on Digital Image Computing Techniques and Applications (DICTA), Noosa, QLD, Australia, 6-8 December 2011. Piscataway, NJ, United States: IEEE. doi: 10.1109/DICTA.2011.57
Venkatachalam, T. K., Pierens, Gregory K. and Reutens, David (2010). Synthesis and characterization of anils exhibiting thermochromism. 11th Pacific Polymer Conference, Cairns, QLD Australia, 6 - 11 December 2009. Clayton, VIC Australia: CSIRO. doi: 10.1071/CH09579
Mobli, M., Lambert, L. K., Pierens, G. K., Dantas de Araujo, A., Alewood, P. F. and King, G. F. (2008). Unequivocal direct determination of the disulfide bond connectivities in proteins using 77Se NMR. 7th Biennial Conference of the Australian and New Zealand Society for Magnetic Resonance (ANZMAG 2008), Couran Cove, Australia, 7-11 December 2008.
Cobine, P. A., Pierens, G., Armitage, I. and Dameron, C. (2001). Zinc binding is required for in vitro folding of copper metallothionein from Neurospora crassa. Intern Proteomics Conf (IPC 2001) - 2nd Pac Rim Conf, Canberra, 1-4 October 2001. Mitcham, Vic: DA Information Services Pty Ltd.
Cobine, P. A., Jones, C. E., Pierens, G. and Dameron, C. (2001). Investigating the copper binding domain of the Cop operon repressor CopY. Intern Proteomics Conf (IPC 2001) - 2nd Pac Rim Conf, Canberra, 1-4 October 2001. Mitcham, Vic: DA Information Services Pty Ltd.
Cobine, P.A., Pierens, G., Armitage, I. and Dameron, C. (2000). The formation of the Neurospora crassa copper metallothionein structure is dependent on zinc binding. BBOCS-1, Griffith University, 27 November 2000. Brisbane: Griffith University.
Abbenante, G., Fairlie, D. P., Sokolenko, N., Gahan, L. R., Cusack, R., Hanson, G. R. and Pierens, G. K. (1996). Effects of conformational constraints in cyclic octapeptides of marine origin. 10th Brisbane Organic Chemistry Symposium, Brisbane, QLD, Australia, 29 November 1996.
Pierens, GK, Buchko, GW, Wang, G, Treleaven, WD, Rozek, A and Cushley, RJ (1995). NMR structural studies of amphipathic helices. XIIth Meeting of the International-Society-of-Magnetic-Resonance (ISMAR 95) - the Next 50 Years, Sydney Australia, Jul 16-21, 1995. LA JOLLA: INT SOC MAGNETIC RESONANCE.
Peyron, M, Pierens, GK, Lucas, AJ, Hall, LD, Potter, GF, Stewart, RC and Phelps, DW (1994). Strategies for Overcoming Linewidth Limitations in Quantitative Petrophysical Nmr Measurements. 2nd International Meeting on Recent Advances in MR Applications to Porous Media, Canterbury England, Apr 14-16, 1993. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/0730-725X(94)91539-3
Peyron, M, Pierens, GK, Lucas, AJ, Hall, LD and Potter, GF (1993). Quantitative Fluid Saturation Profiles Using Nmr Slice Selection. WASHINGTON: AMER CHEMICAL SOC.
Lucas, AJ, Pierens, GK, Peyron, M, Carpenter, TA, Hall, LD, Stewart, RC, Phelps, DW and Potter, GF (1993). Quantitative Porosity Mapping of Reservoir Rock Cores by Physically Slice Selected Nmr. Society-of-Core-Analysts 3rd European Core Analysis Symposium, Paris France, Sep 14-16, 1992. LANGHORNE: GORDON AND BREACH SCIENCE PUBL.