Associate Professor Brett Paterson
Head of Radiochemistry & Group Leader
Centre for Advanced Imaging
Development of chelators and radiotracers for nuclear medicine: Design, synthesis, radiochemistry, and pre-clinical evaluation of radiotracers for targeted molecular imaging, radiotherapy, and drug development.
The Paterson group’s research focuses on developing methods to attach radioactive metal ions to peptides and proteins for use in diagnostic imaging and radiotherapy.
The research program utilises the radionuclides Cu-64, Ga-68, Zr-89, Tc-99m and In-111 for diagnostic imaging. We also pursue potential radiotherapeutic applications with beta-emitting radionuclides Lu-177 and Re-188 and alpha-emitting radionuclides Pb-212, Ac-225 and Ra-223.
The group uses synthetic organic and inorganic chemistry to generate new coordination complexes. We develop the radiochemistry and the bioconjugation procedures to produce constructs for pre-clinical trials imaging disease using positron emission tomography (PET) and single photon emission computed tomography (SPECT) and targeted radiotherapy of tumours.
Researcher biography
Keywords: Radiochemistry, molecular imaging, bioinorganic chemistry, bioconjugation chemistry, theranostics
Associate Professor Brett Paterson is Head of Radiochemistry at The Centre for Advanced Imaging. He is a synthetic inorganic/organic chemist with extensive experience in the design, synthesis and evaluation of radiotracers/radiopharmaceuticals for therapy and imaging applications.
PhD and MPhil Supervision
- View current and completed supervisions on UQ Researchers.
Book Chapter
Paterson, Brett M. and Donnelly, Paul S. (2016). Macrocyclic bifunctional chelators and conjugation strategies for copper-64 radiopharmaceuticals. Insights from Imaging in Bioinorganic Chemistry. (pp. 223-251) edited by Rudi van Eldik and Colin D. Hubbard. San Diego, CA United States: Academic Press. doi: 10.1016/bs.adioch.2015.09.005
Journal Articles
Kelderman, Cormac A. A., Maclean, Rachel C., Hungnes, Ingebjørg N., Davey, Patrick R. W. J., Salimova, Ekaterina, de Veer, Michael, Patel, Natasha, Ma, Michelle T. and Paterson, Brett M. (2023). Technetium nitrido complexes of tetradentate thiosemicarbazones: kit-based radiolabeling, characterization, and in vivo evaluation. Inorganic Chemistry, 62 (50), 20791-20805. doi: 10.1021/acs.inorgchem.3c02650
Reddiar, Sanjeevini Babu, de Veer, Michael, Paterson, Brett M., Sepehrizadeh, Tara, Wai, Dorothy C. C., Csoti, Agota, Panyi, Gyorgy, Nicolazzo, Joseph A. and Norton, Raymond S. (2023). A biodistribution study of the radiolabeled Kv1.3-blocking peptide DOTA-HsTX1[R14A] demonstrates brain uptake in a mouse model of neuroinflammation. Molecular Pharmaceutics, 20 (1), 255-266. doi: 10.1021/acs.molpharmaceut.2c00614
Davey, Patrick R. W. J. and Paterson, Brett M. (2023). Modern developments in bifunctional chelator design for gallium radiopharmaceuticals. Molecules, 28 (1) 203, 1-36. doi: 10.3390/molecules28010203
Morgan, Katherine A., de Veer, Michael, Miles, Luke A., Kelderman, Cormac A. A., McLean, Catriona A., Masters, Colin L., Barnham, Kevin J., White, Jonathan M., Paterson, Brett M. and Donnelly, Paul S. (2023). Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease. Chemical Communications, 59 (16), 2243-2246. doi: 10.1039/d2cc06850h
Crouch, Sophie A., Davey, Patrick R. W. J., Forsyth, Craig M., Batten, Stuart R. and Paterson, Brett M. (2022). A silver(I) coordination polymer with bridging bis(thiosemicarbazone) ligands and unsupported argentophilic interactions. Journal of Coordination Chemistry, 75 (11-14), 1691-1701. doi: 10.1080/00958972.2022.2092845
Paterson, Brett M., White, Jonathan M. and Donnelly, Paul S. (2022). An icosanuclear silver(I) cluster supported by bis(thiosemicarbazonato) ligands. Australian Journal of Chemistry, 75 (9), 631-635. doi: 10.1071/CH21335
Koller, Angus J., Saini, Shefali, Chaple, Ivis F., Joaqui‐Joaqui, M. Andrey, Paterson, Brett M., Ma, Michelle T., Blower, Philip J., Pierre, Valérie C., Robinson, Jerome R., Lapi, Suzanne E. and Boros, Eszter (2022). A general design strategy enabling the synthesis of hydrolysis‐resistant, water‐stable titanium(IV) complexes. Angewandte Chemie, 134 (22). doi: 10.1002/ange.202201211
Davey, Patrick R. W. J., Forsyth, Craig M. and Paterson, Brett M. (2022). Crystallographic and computational characterisation of the potential PET tracer 1,4,7-triazacyclononane-1,4,7-tri(methylenephosphonato)gallium(III). ChemistrySelect, 7 (5) e202103698. doi: 10.1002/slct.202103698
Grieve, Melyssa L. and Paterson, Brett M. (2022). The evolving coordination chemistry of radiometals for targeted alpha therapy. Australian Journal of Chemistry, 75 (2), 65-88. doi: 10.1071/CH21184
Kelderman, Cormac A. A., Davey, Patrick R. W. J., Ma, Michelle T., de Veer, Michael, Salimova, Ekaterina, Donnelly, Paul S. and Paterson, Brett M. (2022). Hexadentate technetium-99m bis(thiosemicarbazonato) complexes: synthesis, characterisation and biodistribution. Dalton Transactions, 51 (37), 14064-14078. doi: 10.1039/d2dt01264b
Grieve, Melyssa L., Davey, Patrick R. W. J., Forsyth, Craig M. and Paterson, Brett M. (2021). The synthesis of a bis(Thiosemicarbazone) macrocyclic ligand and the Mn(II), Co(II), Zn(II) and 68Ga(III) complexes. Molecules, 26 (12) 3646. doi: 10.3390/molecules26123646
Lange, Jaclyn L., Davey, Patrick R. W. J., Ma, Michelle T., White, Jonathan M., Morgenstern, Alfred, Bruchertseifer, Frank, Blower, Philip J. and Paterson, Brett M. (2020). An octadentate bis(semicarbazone) macrocycle: a potential chelator for lead and bismuth radiopharmaceuticals. Dalton Transactions, 49 (42), 14962-14974. doi: 10.1039/d0dt02673e
Cui, Jiwei, Ju, Yi, Houston, Zachary H., Glass, Joshua J., Fletcher, Nicholas L., Alcantara, Sheilajen, Dai, Qiong, Howard, Christopher B., Mahler, Stephen M., Wheatley, Adam K., De Rose, Robert, Brannon, Paul T., Paterson, Brett M., Donnelly, Paul S., Thurecht, Kristofer J., Caruso, Frank and Kent, Stephen J. (2019). Modulating targeting of poly(ethylene glycol) particles to tumor cells using bispecific antibodies. Advanced Healthcare Materials, 8 (9) 1801607, e1801607. doi: 10.1002/adhm.201801607
Paterson, Brett M., Cullinane, Carleen, Crouch, Peter J., White, Anthony R., Barnham, Kevin J., Roselt, Peter D., Noonan, Wayne, Binns, David, Hicks, Rodney J. and Donnelly, Paul S. (2019). Modification of biodistribution and brain uptake of copper bis(thiosemicarbazonato) complexes by the incorporation of amine and polyamine functional groups. Inorganic Chemistry, 58 (7), 4540-4552. doi: 10.1021/acs.inorgchem.9b00117
Imberti, Cinzia, Chen, Yu-Lin, Foley, Calum A., Ma, Michelle T., Paterson, Brett M., Wang, Yifu, Young, Jennifer D., Hider, Robert C. and Blower, Philip J. (2019). Tuning the properties of tris(hydroxypyridinone) ligands: efficient 68 Ga chelators for PET imaging. Dalton Transactions, 48 (13), 4299-4313. doi: 10.1039/c8dt04454f
Hicks, Rodney J., Jackson, Price, Kong, Grace, Ware, Robert E., Hofman, Michael S., Pattison, David A., Akhurst, Timothy A., Drummond, Elizabeth, Roselt, Peter, Callahan, Jason, Price, Roger, Jeffery, Charmaine M., Hong, Emily, Noonan, Wayne, Herschtal, Alan, Hicks, Lauren J., Hedt, Amos, Harris, Matthew, Paterson, Brett M. and Donnelly, Paul S. (2018). 64Cu-SARTATE PET imaging of patients with neuroendocrine tumors demonstrates high tumor uptake and retention, potentially allowing prospective dosimetry for peptide receptor radionuclide therapy. Journal of Nuclear Medicine, 60 (6), 777-785. doi: 10.2967/jnumed.118.217745
Tsionou, Maria Iris, Knapp, Caroline E., Foley, Calum A., Munteanu, Catherine R., Cakebread, Andrew, Imberti, Cinzia, Eykyn, Thomas R., Young, Jennifer D., Paterson, Brett M., Blower, Philip J. and Ma, Michelle T. (2017). Comparison of macrocyclic and acyclic chelators for gallium-68 radiolabelling. RSC Advances, 7 (78), 49586-49599. doi: 10.1039/c7ra09076e
Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Frontispiece: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie International Edition, 56 (29). doi: 10.1002/anie.201782961
Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Frontispiz: Guest-induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie, 129 (29). doi: 10.1002/ange.201782961
Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Guest‐induced Assembly of Bis(thiosemicarbazonato) Zinc(II) Coordination Nanotubes. Angewandte Chemie, 129 (29), 8490-8494. doi: 10.1002/ange.201701596
Paterson, Brett M., White, Keith F., White, Jonathan M., Abrahams, Brendan F. and Donnelly, Paul S. (2017). Guest-induced assembly of bis(thiosemicarbazonato) zinc(II) coordination nanotubes. Angewandte Chemie - International Edition, 56 (29), 8370-8374. doi: 10.1002/anie.201701596
Ziegler, Melanie, Alt, Karen, Paterson, Brett M., Kanellakis, Peter, Bobik, Alex, Donnelly, Paul S., Hagemeyer, Christoph E. and Peter, Karlheinz (2016). Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets. Scientific Reports, 6 (1) 38161. doi: 10.1038/srep38161
Gourni, Eleni, Del Pozzo, Luigi, Kheirallah, Emilie, Smerling, Christiane, Waser, Beatrice, Reubi, Jean-Claude, Paterson, Brett M., Donnelly, Paul S., Meyer, Philipp T. and Maecke, Helmut R. (2015). Copper-64 Labeled Macrobicyclic Sarcophagine Coupled to a GRP Receptor Antagonist Shows Great Promise for PET Imaging of Prostate Cancer. Molecular Pharmaceutics, 12 (8), 2781-2790. doi: 10.1021/mp500671j
Alt, Karen, Paterson, Brett M., Westein, Erik, Rudd, Stacey E., Poniger, Stan S., Jagdale, Shweta, Ardipradja, Katie, Connell, Timothy U., Krippner, Guy Y., Nair, Ashish K. N., Wang, Xiaowei, Tochon-Danguy, Henri J., Donnelly, Paul S., Peter, Karlheinz and Hagemeyer, Christoph E. (2015). A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry. Angewandte Chemie - International Edition, 54 (26), 7515-7519. doi: 10.1002/anie.201411507
Dearling, Jason L. J., Paterson, Brett M., Akurathi, Vamsidhar, Betanzos-Lara, Soledad, Treves, S. Ted, Voss, Stephan D., White, Jonathan M., Huston, James S., Smith, Suzanne V., Donnelly, Paul S. and Packard, Alan B. (2015). The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution. Bioconjugate Chemistry, 26 (4), 707-717. doi: 10.1021/acs.bioconjchem.5b00049
Ma, Michelle T., Meszaros, Levente K., Paterson, Brett M., Berry, David J., Cooper, Maggie S., Ma, Yongmin, Hider, Robert C. and Blower, Philip J. (2015). Tripodal tris(hydroxypyridinone) ligands for immunoconjugate PET imaging with 89Zr4+: Comparison with desferrioxamine-B. Dalton Transactions, 44 (11), 4884-4900. doi: 10.1039/c4dt02978j
Cui, Jiwei, De Rose, Robert, Alt, Karen, Alcantara, Sheilajen, Paterson, Brett M., Liang, Kang, Hu, Ming, Richardson, Joseph J., Yan, Yan, Jeffery, Charmaine M., Price, Roger I., Peter, Karlheinz, Hagemeyer, Christoph E., Donnelly, Paul S., Kent, Stephen J. and Caruso, Frank (2015). Engineering poly(ethylene glycol) particles for improved biodistribution. ACS Nano, 9 (2), 1571-1580. doi: 10.1021/nn5061578
Paterson, Brett M., Buncic, Gojko, McInnes, Lachlan E., Roselt, Peter, Cullinane, Carleen, Binns, David S., Jeffery, Charmaine M., Price, Roger I., Hicks, Rodney J. and Donnelly, Paul S. (2015). Bifunctional 64Cu-labelled macrobicyclic cage amine isothiocyanates for immuno-positron emission tomography. Dalton Transactions, 44 (11), 4901-4909. doi: 10.1039/c4dt02983f
Noor, Asif, Huff, Gregory S., Kumar, Sreedhar V., Lewis, James E. M., Paterson, Brett M., Schieber, Christine, Donnelly, Paul S., Brooks, Heather J. L., Gordon, Keith C., Moratti, Stephen C. and Crowley, James D. (2014). + complexes of exo-functionalized tridentate "click" macrocycles: Synthesis, stability, photophysical properties, bioconjugation, and antibacterial activity. Organometallics, 33 (24), 7031-7043. doi: 10.1021/om500664v
Alt, Karen, Paterson, Brett M., Ardipradja, Katie, Schieber, Christine, Buncic, Gojko, Lim, Bock, Poniger, Stan S., Jakoby, Bjoern, Wang, Xiaowei, Okeefe, Graeme J., Tochon-Danguy, Henri J., Scott, Andrew M., Ackermann, Uwe, Peter, Karlheinz, Donnelly, Paul S. and Hagemeyer, Christoph E. (2014). Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets. Molecular Pharmaceutics, 11 (8), 2855-2863. doi: 10.1021/mp500209a
Paterson, Brett M., Alt, Karen, Jeffery, Charmaine M., Price, Roger I., Jagdale, Shweta, Rigby, Sheena, Williams, Charlotte C., Peter, Karlheinz, Hagemeyer, Christoph E. and Donnelly, Paul S. (2014). Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody. Angewandte Chemie - International Edition, 53 (24), 6115-6119. doi: 10.1002/anie.201402613
Bica, Laura, Liddell, Jeffrey R., Donnelly, Paul S., Duncan, Clare, Caragounis, Aphrodite, Volitakis, Irene, Paterson, Brett M., Cappai, Roberto, Grubman, Alexandra, Camakaris, James, Crouch, Peter J. and White, Anthony R. (2014). Neuroprotective copper bis(thiosemicarbazonato) complexes promote neurite elongation. PLoS ONE, 9 (2) e90070. doi: 10.1371/journal.pone.0090070
Paterson, Brett M., Roselt, Peter, Denoyer, Delphine, Cullinane, Carleen, Binns, David, Noonan, Wayne, Jeffery, Charmaine M., Price, Roger I., White, Jonathan M., Hicks, Rodney J. and Donnelly, Paul S. (2014). PET imaging of tumours with a 64Cu labeled macrobicyclic cage amine ligand tethered to Tyr3-octreotate. Dalton Transactions, 43 (3), 1386-1396. doi: 10.1039/c3dt52647j
Djoko, Karrera Y., Paterson, Brett M., Donnelly, Paul S. and McEwan, Alastair G. (2014). Antimicrobial effects of copper(II) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action. Metallomics, Advance Article (4), 1-10. doi: 10.1039/C3MT00348E
Roberts, Blaine R., Lim, Nastasia K. H., McAllum, Erin J., Donnelly, Paul S., Hare, Dominic J., Doble, Philip A., Turner, Bradley J., Price, Katherine A., Lim, Sin Chun, Paterson, Brett M., Hickey, James L., Rhoads, Timothy W., Williams, Jared R., Kanninen, Katja M., Hung, Lin W., Liddell, Jeffrey R., Grubman, Alexandra, Monty, Jean-Francois, Llanos, Roxana M., Kramer, David R., Mercer, Julian F. B., Bush, Ashley I., Masters, Colin L., Duce, James A., Li, Qiao-Xin, Beckman, Joseph S., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2014). Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience, 34 (23), 8021-8031. doi: 10.1523/JNEUROSCI.4196-13.2014
McAllum, Erin J., Lim, Nastasia K.-H., Hickey, James L., Paterson, Brett M., Donnelly, Paul S., Li, Qiao-Xin, Liddell, Jeffrey R., Barnham, Kevin J., White, Anthony R. and Crouch, Peter J. (2013). Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14 (7-8), 586-590. doi: 10.3109/21678421.2013.824000
Hickey, James L., Lim, Sinchun, Hayne, David J., Paterson, Brett M., White, Jonathan M., Villemagne, Victor L., Roselt, Peter, Binns, David, Cullinane, Carleen, Jeffery, Charmaine M., Price, Roger I., Barnham, Kevin J. and Donnelly, Paul S. (2013). Diagnostic imaging agents for alzheimer's disease: Copper radiopharmaceuticals that target aβ plaques. Journal of the American Chemical Society, 135 (43), 16120-16132. doi: 10.1021/ja4057807
Cater, Michael A., Pearson, Helen B., Wolyniec, Kamil, Klaver, Paul, Bilandzic, Maree, Paterson, Brett M., Bush, Ashley I., Humbert, Patrick O., La Fontaine, Sharon, Donnelly, Paul S. and Haupt, Ygal (2013). Increasing intracellular bioavailable copper selectively targets prostate cancer cells. ACS Chemical Biology, 8 (7), 1621-1631. doi: 10.1021/cb400198p
Duncan, Clare, Bica, Laura, Crouch, Peter J., Caragounis, Aphrodite, Lidgerwood, Grace E., Parker, Sarah J., Meyerowitz, Jodi, Volitakis, Irene, Liddell, Jeffrey R., Raghupathi, Ravinarayan, Paterson, Brett M., Duffield, Michael D., Cappai, Roberto, Donnelly, Paul S., Grubman, Alexandra, Camakaris, James, Keating, Damien J. and White, Anthony R. (2013). Copper modulates the large dense core vesicle secretory pathway in PC12 cells. Metallomics, 5 (6), 700-714. doi: 10.1039/c3mt20231c
Kanninen, Katja M., Grubman, Alexandra, Meyerowitz, Jodi, Duncan, Clare, Tan, Jiang-Li, Parker, Sarah J., Crouch, Peter J., Paterson, Brett M., Hickey, James L., Donnelly, Paul S., Volitakis, Irene, Tammen, Imke, Palmer, David N. and White, Anthony R. (2013). Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis. PLoS ONE, 8 (3) e58644. doi: 10.1371/journal.pone.0058644
Parker, Sarah J., Meyerowitz, Jodi, James, Janine L., Liddell, Jeffrey R., Nonaka, Takashi, Hasegawa, Masato, Kanninen, Katja M., Lim, SinChun, Paterson, Brett M., Donnelly, Paul S., Crouch, Peter J. and White, Anthony R. (2012). Inhibition of TDP-43 accumulation by Bis(thiosemicarbazonato)-copper complexes. PLoS ONE, 7 (8) e42277. doi: 10.1371/journal.pone.0042277
Donnelly, Paul S., Liddell, Jeffrey R., Lim, SinChun, Paterson, Brett M., Cater, Michael A., Savva, Maria S., Mot, Alexandra I., James, Janine L., Trounce, Ian A., White, Anthony R. and Crouch, Peter J. (2012). An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copper II . Proceedings of the National Academy of Sciences of the United States of America, 109 (1), 47-52. doi: 10.1073/pnas.1116227108
Price, Katherine Ann, Crouch, Peter J., Lim, Sinchun, Paterson, Brett M., Liddell, Jeffrey R., Donnelly, Paul S. and White, Anthony R. (2011). Subcellular localization of a fluorescent derivative of Cu II(atsm) offers insight into the neuroprotective action of Cu II(atsm). Metallomics, 3 (12), 1280-1290. doi: 10.1039/c1mt00092f
Price, Katherine Ann, Crouch, Peter J., Volitakis, Irene, Paterson, Brett M., Lim, Sinchun, Donnelly, Paul S. and White, Anthony R. (2011). Mechanisms controlling the cellular accumulation of copper bis(thiosemicarbazonato) complexes. Inorganic Chemistry, 50 (19), 9594-9605. doi: 10.1021/ic201334q
Paterson, Brett M. and Donnelly, Paul S. (2011). Copper complexes of bis(thiosemicarbazones): From chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals. Chemical Society Reviews, 40 (5), 3005-3018. doi: 10.1039/c0cs00215a
Bica, Laura, Meyerowitz, Jodi, Parker, Sarah J., Caragounis, Aphrodite, Du, Tai, Paterson, Brett M., Barnham, Kevin J., Crouch, Peter J., White, Anthony R. and Donnelly, Paul S. (2011). Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex. BioMetals, 24 (1), 117-133. doi: 10.1007/s10534-010-9380-7
Lim, Sinchun, Paterson, Brett M., Fodero-Tavoletti, Michelle T., O'Keefe, Graeme J., Cappai, Roberto, Barnham, Kevin J., Villemagne, Victor L. and Donnelly, Paul S. (2010). A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: A bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaques. Chemical Communications, 46 (30), 5437-5439. doi: 10.1039/c0cc01175d
Buncic, Gojko, Donnelly, Paul S., Paterson, Brett M., White, Jonathan M., Zimmermann, Matthias, Xiao, Zhiguang and Wedd, Anthony G. (2010). A water-soluble bis(thiosemicarbazone) ligand. A sensitive probe and metal buffer for zinc. Inorganic Chemistry, 49 (7), 3071-3073. doi: 10.1021/ic902370a
Paterson, Brett M., White, Jonathan M. and Donnelly, Paul S. (2010). A hexadentate bis(thiosemicarbazonato) ligand: Rhenium(v), iron(iii) and cobalt(iii) complexes. Dalton Transactions, 39 (11), 2831-2837. doi: 10.1039/b922127a
Brett M. Paterson, M. Paterson, John A. Karas, A. Karas, Denis B. Scanlon, B. Scanlon, Jonathan M. White, M. White and Donnelly, Paul S. (2010). Versatile new bis(thiosemicarbazone) bifunctional chelators: Synthesis, conjugation to bombesin(7-14)-NH2, and copper-64 radiolabeling. Inorganic Chemistry, 49 (4), 1884-1893. doi: 10.1021/ic902204e
Lim, Sinchun, Price, Katherine A., Chong, Siow-Feng, Paterson, Brett M., Caragounis, Aphrodite, Barnham, Kevin J., Crouch, Peter J., Peach, Josephine M., Dilworth, Jonathan R., White, Anthony R. and Donnelly, Paul S. (2010). Copper and zinc bis(thiosemicarbazonato) complexes with a fluorescent tag: Synthesis, radiolabelling with copper-64, cell uptake and fluorescence studies. Journal of Biological Inorganic Chemistry, 15 (2), 225-235. doi: 10.1007/s00775-009-0587-4
Fodero-Tavoletti, Michelle T., Villemagne, Victor L., Paterson, Brett M., White, Anthony R., Li, Qiao-Xin, Camakaris, James, O'keefe, Graeme, Cappai, Roberto, Barnham, Kevin J. and Donnelly, Paul S. (2010). Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease. Journal of Alzheimer's Disease, 20 (1), 49-55. doi: 10.3233/JAD-2010-1359
Price, Katherine Ann, Caragounis, Aphrodite, Paterson, Brett M., Filiz, Gulay, Volitakis, Irene, Masters, Colin L., Barnham, Kevin J., Donnelly, Paul S., Crouch, Peter J. and White, Anthony R. (2009). Sustained activation of glial cell epidermal growth factor receptor by bis(thiosemicarbazonato) metal complexes is associated with inhibition of protein tyrosine phosphatase activity. Journal of Medicinal Chemistry, 52 (21), 6606-6620. doi: 10.1021/jm9007938
Christlieb, Martin, Cowley, Andrew R., Dilworth, Jonathan R., Donnelly, Paul S., Paterson, Brett M., Struthers, Harriet S. R. and White, Jonathan M. (2007). New bimetallic compounds based on the bis(thiosemicarbazonato) motif. Dalton Transactions (3), 327-331. doi: 10.1039/b612907b
Conference Paper
Lim, Ting Xiang, Migotto, Mary-Anne, Mardon, Karine, Paterson, Brett and Reutens, David (2023). Targeting the aryl hydrocarbon receptor to monitor the kynurenine pathway in glioblastoma multiforme using fluorine-18 PET radiotracers. International Symposium on Radiopharmaceutical Sciences iSRS 2023, Honolulu, HI, United States, 22-26 May 2023. Philadelphia, PA, United States: Elsevier.